Dr. Lynn Denlon (Bahar Soomekh) becomes a pawn in the Jigsaw Killer's (Tobin Bell) latest gory game. Kidnapped and taken to an abandoned warehouse, she finds Jigsaw bedridden and dying. Her task is to keep the maniac alive long enough for Jeff (Angus Macfadyen), a fellow victim, to complete his own task. Each is unaware that Jigsaw has much bigger -- and deadlier -- plans in store.